It would seem that GOG’s plan to unbundle various game collections of theirs — several Ultima titles included — has required Pix to make one more update to his venerable Ultima Patcher:

I wasn’t expecting to do another release so soon but GOG recently split all their bundled games into individual downloads which broke MT-32 emulation support. Version 1.61 fixes this + will look for the games in the new default installation locations. It can be downloaded here.

This new version isn’t entirely backwards compatible so I’ve left 1.60 on the downloads page for anyone who wants it.

Both versions — 1.60 and 1.61 — can also be found on the Patcher’s project entry here.